Effects of exogenous lactase administration on hydrogen breath excretion and intestinal symptoms in patients with lactose malabsorption and intolerance
To assess oral lactase (β-galactosidase from Aspergillus oryzae) taken 1 hour before lactose intake in 96 patients with lactose malabsorption and intolerance, confirmed by breath hydrogen testing. Patients had typical symptoms after lactose: diarrhoea, abdominal pain, nausea, bloating and gas.
• Mean peak hydrogen levels and cumulative breath hydrogen excretion decreased significantly in approximately 40% of subjects.
• The symptom score fell significantly in all study groups (except nausea), mainly abdominal pain and diarrhoea.
Conclusion: Oral lactase significantly reduced hydrogen excretion and intestinal symptoms after lactose intake.
Ibba I, Gilli A, Boi MF, Usai P. Biomed Res Int. 2014;2014:680196.